Renewable resources, biopolymers and bio-based materials are keywords of the sustainable development and environmental
sustainability concepts. Biopolymers, the green alternatives to fossil fuel based polymers, have already found different feasible
applications, from consumer goods to regenerative medicine. Keratin is the biopolymer contained in the skin derivatives and
appendages and is one of the the proteins with the most sophisticated architecture nature could produce. It is found in huge
quantities in materials regarded as by-products or wastes with negative environmental impact but with high potential, for which it
is desirable to develop valorization solutions. The increased interest towards biopolymers and renewable resources determined a
large body of research and practical work concerning keratin extraction from different sources and regeneration into useful
products. It is the aim of this paper to review the conventional chemical pathways and environmentally friendly alternatives for
keratin solubilization as it regards the mechanisms, process parameters, characteristics of the obtained keratin forms,
environmental and economical aspects. Current and possible applications of the solubilized keratin forms are also shortly
reviewed.